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The International Union Against Cancer (UICC) System is used to distinguish the stages of liver cancer. Stage I consists of a single tumor no larger than 2 cm (about ¾ inch) in size, with no progression into the blood vessels. Patients with Stage I have the best prognosis.
Stage II is a more advanced disease with vascular (blood vessel) involvement and/or tumor(s) larger than 2 cm (3/4 inches) in diameter. Cancer in the blood vessels provides a route for malignant cells to move to other sites and has a significant negative effect on prognosis. Large tumors are also more likely to be associated with vascular involvement.
Stage III disease generally indicates disease progression in which the tumors are large and may include lymph node and vascular involvement. When patients are initially diagnosed at this stage, prognosis for survival is usually less than one year.
Stage IV disease reflects widespread, significant malignant lesions as well as vascular invasion and lymph node involvement. Prognosis for patients with this late stage disease is poor. Few patients survive more than one year after transplantation or surgery.
(Mon Jul 8, 2002 - 12:51:39 pm)